The microgravity environment of the ISS provides a unique window to explore fundamental phenomena in the absence of gravity-dependent physics and introduces new biological stressors to cells and tissues. The ISS National Lab has partnered with the NSF Chemical, Bioengineering, Environmental, and Transport Systems (CBET) Division on two long-standing solicitations to explore these phenomena: The solicitation on transport phenomena is going on its seventh year, and the solicitation on tissue engineering and mechanobiology is going on its fifth year. Research funded through these solicitations enables scientific discoveries not possible on Earth. Join us to hear more about this exciting research and the impact that fundamental science in space can have on life on Earth.