As part of the 2021 ISS Research and Development Conference (ISSRDC), three days of technical sessions were held from August 16th through the 18th. These sessions explored many engaging topics, including biology and medicine, computing, physical sciences and material development, commercialization and nongovernment utilization, human health in space, STEM education, and technology development and demonstration. In all, over 60 presentations and posters were included in this portion of the ISSRDC.